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Dan Larhammar CV

Table of contents:

1. Personal data

Date of birth

1 April 1956

Nationality

Swedish

Marital status

Married

Family

Wife: Helén Larhammar (pharmacist, head of Larhammar Consulting)
Son: Martin Larhammar (born 1985)
Daughter: Malin Larhammar (born 1987)

2. Academic degrees

Professor of Molecular Cell Biology at Faculty of Medicine, Uppsala University, since November 1, 1994.

Docent of Medical Genetics at Faculty of Medicine, Uppsala University, February 27, 1987.

Doctor of Medical Science at Faculty of Medicine, Uppsala University, January 20, 1984.
Thesis: Class II transplantation antigens: Molecular Genetic Studies. Supervisor: Prof. Per A. Peterson.

Master of Pharmacy ("Farmacie magister") at Faculty of Pharmacy, Uppsala University, January 18, 1980.

3. Positions

Since November 1994: Professor of Molecular Cell Biology at Faculty of Medicine, Uppsala University.

October 1994: University lecturer (associate professor) in molecular cell biology at Faculty of Science, Uppsala University.

October 1988-September 1994: Researcher ("Forskartjänst") in molecular cell biology. Position provided by the Swedish Natural Science Research Council.

October 1987-September 1988: Visiting scientist (EMBO long-term fellowship) at Research Inst. of Scripps Clinic, La Jolla, U.S.A., Division of Preclinical Neuroscience and Endocrinology, Head: Dr. Floyd E. Bloom.

December 1985-September 1987: Research associate ("forskarassistent") in molecular genetics at Uppsala University, Dept of Medical Genetics. Head: Professor Ulf Pettersson.

Sept-Nov 1985: Parental leave 3 months.

Feb-Nov 1985: Research associate ("forskarassistent") in medical-chemical science at Uppsala University, Dept of Cell Research. Head: Professor Per A. Peterson.

July 1984-Jan 1985: Postdoctoral fellow at Bionova (owned by Pharmacia and STU, "Styrelsen för teknisk utveckling"). Research was done at the Department of Cell Research. Head: Professor Per A. Peterson.

1980-1984: Ph. D. student at the Department of Cell Research, Uppsala University (Supervisor: Professor Per A. Peterson).

4. Supervised Ph. D. and licentiate theses and postdoctoral fellows

Anders G. Blomqvist 1994 Ph. D. thesis: Molecular characterization of the neuropeptide Y family and the NPY receptor Y1.
Carl Risinger 1995 Ph. D. thesis: Evolution of the synapse protein SNAP-25.
Charlotte Söderberg 1996 Ph. D. thesis: Molecular evolution of the neuropeptide Y family of peptides.
Ingrid Lundell 1997 Ph. D. thesis: Cloning and characterisation of receptors for the neuropeptide Y family of peptides.
Charlotta Grånäs 1998 Ph. D. thesis: Molecular mechanisms of human 5-HT1B receptor function.
Henrik Eriksson 1998 Licentiate thesis: Cloning and characterization of NPY family receptors in the guinea pig.
Magnus M. Berglund 1999 Ph. D. thesis: Cloning and structure-activity relationship studies of neuropeptide Y receptors belonging to the Y1 subfamily.
Amanda Wraith 1999 Ph. D. thesis: Molecular evolution of the neuropeptide Y receptor family; Insights from mammals and fish.
Paula Starbäck 2000 Ph. D. thesis: Cloning and characterization of neuropeptide Y receptors of the Y1 subfamily in mammals and fish.
Erik Salaneck 2001 Ph. D. thesis: Molecular evolution of neuropeptide Y receptors in vertebrates.
Sara Holmberg 2001 Ph. D. thesis: Neuropeptide Y receptors in human, guinea pig and chicken. Cloning, in vitro pharmacology and in situ hybridization.
Robert Fredriksson 2002 Ph. D. thesis: Evolution and pharmacology of neuropeptide Y receptors. Implications for vertebrate genome duplications.
Karin Nordström (cosupervisor) 2003 Ph. D. thesis: Evolution of eyes: Pax, gene duplications & morphology.
Aneta Ringholm (cosupervisor) 2004 Ph. D. thesis: Cloning, expression, pharmacological characterization and anatomical distribution of melanocortin receptors in an evolutionary perspective.
Paula Sjödin 2005 Ph. D. thesis: Pharmacological studies of four neuropeptide Y-family receptor subtypes.
Torun Bromée 2005 Ph. D. thesis: Evolution and pharmacology of receptors for bradykinin and neuropeptide Y in vertebrates.
Tomas A. Larsson 2007 Ph. D. thesis: Evolution of the neuropeptide Y system in vertebrates with focus on fishes.
Helena Åkerberg 2009 Ph. D. thesis: Functional studies of the neuropeptide Y system: Receptor-ligand interaction and regulation of food intake.
Görel Sundström 2010 Ph. D. thesis: Evolution of the neuropeptide Y and opioid systems and their genomic regions.
Helena Fällmar 2011 Ph. D. thesis: Studies of the neuropeptide Y receptor Y2 in human and zebrafish.
Daniel Ocampo Daza 2013 Ph. D. thesis: Evolution of Vertebrate Endocrine and Neuronal Gene Families: Focus on Pituitary and Retina
Bo Xu 2014 Ph. D. thesis: Evolutionary and Pharmacological Studies of NPY and QRFP receptors
David Lagman 2015 Ph. D. Thesis: Evolution of Vertebrate Vision by Means of Whole Genome Duplications. Zebrafish as a Model fo Gene Specialization

Postdoctoral fellows and visiting scientists

Dr. Douglas L. Feinstein (USA) 1989 (5 months) (visiting scientist)
Dr. Elena Jazin (Argentina) 1992-1993 (8 months)
Dr. Sofia Mikko (Sweden) 1997-1998 (1 year 2 months)
Dr. Parul Sharma (India/USA) 1997-1998 (1 year 9 months)
Dr. Ann-Kristin Arvidsson (Sweden) 1997-1999 (2 years 10 months)
Dr. Earl Larson (USA) 1999-2003 (4 years)
Dr. Anne Lecklin (Finland) 2001-2002 (1 year 10 months)
Dr. Erik Salaneck (Sweden) 2003-2004 (10 months)
Dr. Tomas A. Larsson (Sweden) 2007-2008 (11 months)
Dr. Xesus Abalo (Spain) 2010-2012
Dr. Görel Sundström (Sweden) 2010-2011
Dr. Bo Xu (China) 2015-

5. Research group

Employees Christina Bergqvist, research engineer, since July 1996.
Researcher Dr. Xesus (Chus) Abalo, since March 2010.
Dr. Bo Xu, since April 2015.
Ph. D. students Jasna Pruner, registered 2011.
Kateryna Shebanits, registered 2013.
Helen Haines, registered 2015.

6. External research grants (selected)

Swedish Research Council (VR): Grants since 1985; 945+405 kkr/year 2004-05; 945 kkr/year 2006; 900 kkr/year 2007-09, 900 kkr/year 2010-12; 700 kkr/year 2013-15; 985 kkr/year 2013-14.

SJFR/STINT: 710 kkr/year 2001-02

Swedish Medical Research Council (MFR): 1989-93 (Narcolepsy and HLA)

SSF (Stiftelsen f Strategisk Forskning), NNN(National Network in Neuroscience): Ph. D. student position Feb. 98-Jan 2001.

Wenner-Gren Foundations: 144 kkr 2000 (postdoc fellowship)

Wenner-Grenska samfundet: 150 kkr 1997 (postdoc fellowship)

Carl Trygger's Foundation: 276 kkr 2003; 120 kkr 2007; 340 kkr 2009.

Göran Gustafsson’s Foundation: 535 kkr 1994 (equipment grant)

7. Memberships in scientific organizations

Member of the Society for Neuroscience since 1987.
Member of the New York Academy of Science 1989-2002, 2005-2012.
Member of the European Society for Comparative Endocrinology since 1990.
Member of the American Association for the Advancement of Science since 1994-2012.
Member of the Swedish Academy of Pharmaceutical Sciences (Apotekarsocieteten) since 1997.
Associate member of CSI (Committee for Skeptical Inquiry) since 1997 (formerly CSICOP).

8. Honours and awards (selection)

Selected to give the prestigious Bargmann-Scharrer lecture at the International Conference of Comparative Endocrinology in Hong Kong, 2009. The conference is organized by the International Federation of Comparative Endocrinology Societies (IFCES). The lecture is named after the founders of the concept of neurosecretion and this was the eighth lecture since its inauguration in 1981.

Elected member in 2007 of the Royal Swedish Academy of Sciences (founded 1739). Elected 3rd Vice President of the Academy and Chairperson for its permanent Education Committee 150701-180630. This also entails membership of the Presiding Committee and the Academy Board.

Research programme was judged to be of internationally high standad (second highest category) in the international evaluation of research at Uppsala University in 2011 as well as in 2007.

Awarded the first “wight” (in Swedish: “Folkvätte”) anti-prize by the Swedish pseudoscientific and alternative medicine organization SARA in 2006. SARA was formed in 1990 and publishes a pseudoscientific web journal called Science of the 2000s (in Swedish: “2000-talets vetenskap”). One of SARA’s proponents is the former physician Erik Enby whose licence has been withdrawn due to his use of non-evidence based methods. SARA supports a broad range of pseudoscientific and non-sensical therapies like homeopathy and footzone therapy and propagates conspiracy theories about the origin of HIV. They advertise dubious commercial products like noni juice and mangosteen. They have given their “positive” prize called “the spark” (in Swedish: “gnistan”) to several proponents of pseudoscientific therapies. I consider their "anti-prize" to me as a recogniction that my efforts to question and criticize pseudoscientific alternative medicine in Sweden has been successful.

Awarded the Rosén Linnaeus Prize in Zoology 2004 by the Physiographic Society in Lund (founded 1772).

Awarded the "Pedagogical Rose" teaching award in May 2013 by the Medical Student Association at Uppsala University.

Awarded the "Limbic Prize" (a teaching award) 2003 by the Biomedical Student Association at Uppsala University. Nominated for the prize also in 2002, 2004, and 2005.

Nominated for the "Inspiriet" prize (for valuable work for the medical students) 2005 and 2006 by the Medical Student Association at Uppsala University.

Elected member in 2000 of the Royal Society of Sciences in Uppsala (founded 1710).

Awarded the Ingemar Hedenius prize 2000 by the Swedish Humanist Organization "Humanisterna" (The Swedish branch of IHEU, The International Humanist and Ethical Union).

Research programme was awarded the grade "excellent" (highest grade) in NFR:s international evaluation of neurobiology projects supported by the NFR (July 1999).

Selected to give the Bengt Danielsson lecture 1998 at the annual Pharmaceuticals Congress (Läkemedelskongressen) organized by the Swedish Academy of Pharmaceutical Sciences (Apotekarsocieteten).

EMBO long-term postdoctoral fellowship 1987-88.

9. Assignments (selected)

President of the European Society for Comparative Endocrinology (ESCE) 2010-2014. Vice president 2006-10.

Councillor of the International Federation of Comparative Endocrine Societies (IFCES) 2005-09.

Councillor of the European Society for Comparative Endocrinology (ESCE) 1994-98 and 2002-2006.

Within the Royal Swedish Academy of Sciences (RSAS), I was a member of the permanent Education Committee (Kungl. Vetenskapsakademiens kommitté för skolfrågor) during 2008-2014. I am chairman of the committe since July 2015. Member of the School of the Future Committee since it was started in 2010, chairperson 2011-2015.

Ad hoc manuscript peer reviewer on more than 180 occasions for more than 50 journals.

Associate editor for Frontiers in Neuroendocrine Science since 2010.

Member of the editorial board of General and Comparative Endocrinology since 2001. Guest editor for special issue on the evolution of G protein-coupled receptors for peptide hormones 2014.

Member of the international editorial board of FACT, Focus on Alternative and Complementary Therapies, an official journal of the Royal Pharmaceutical Society (U.K.) since 2011.

Member of the board for the Disciplinary Domain (“områdesnämnden”) of Medicine and Pharmacy at Uppsala University 2011-14 and 2014-17.

Member of the Expert Group on Research Misconduct ("expertgrupp för frågor om oredlighet i forskningen") at the Swedish Research Council (Vetenskapsrådet) 2002-2010.

Member of the Scientific Committee of The Brain Foundation (Hjärnfonden) 2006-2010.

Member of the Swedish National Committee for Biology of the Royal Swedish Academy of Sciences since 2002. Chairperson 2005-08.

Member of the board for the Section of Pharmacology (Sektionen för läkemedelslära) of the Swedish Medical Society (Svenska Läkaresällskapet) 2006-2009.

Member of the board for Uppsala Center for Gender Research 2003-2006.

Deputy member of the board for the National Resource Center for Biology and Biotechnology (Bioresurs) 2002-06 and from 2012 (www.bioresurs.uu.se).

Member of the Biology Committee of the Swedish Natural Science Research Council (NFR) 1999-2000.

Chairperson of the Information Committee of the Swedish Natural Science Research Council (NFR) 1999-2000.

Chairman of "Föreningen Vetenskap och Folkbildning" 1998-2004, a non-profit association with the aim to increase public understanding of scientific methods and to debunk pseudoscientific claims such as creationism, astrology and dowsing. Board member since 1997. (VoF is the Swedish equivalent of the U.S. skeptic organization CSICOP, Committee for the Scientific Investigation of Claims of the Paranormal.)
 

External thesis examiner (Faculty Opponent) at 13 dissertations:

Stockholm University 1991
Norwegian Agricultural University 1992
Stockholm University 1997
Tartu University, Estonia 1999
Malmö University Hospital 1999
Linköping University 2003
University of Copenhagen 2003
Karolinska Institute 2004
Norwegian University for Life Sciences (Universitetet for Miljø- og Biovitenskap), 2007
University of Tromsø, Norwegian College of Fishery Science, 2012

10. Symposia

I have organized the following symposia:

Molecular Neurobiology, Uppsala BMC Summer Program, Aug. 10-13 1994. 80 participants. (Together with Prof. Sven Påhlman and Ass. Prof. Göran Andersson.)

Nordic-Baltic Symposium on Heptahelix Receptors, Uppsala BMC Summer Program, Aug. 15-16 1996. 100 participants.

Uppsala Neuroscience Meeting, 1995-99 (five occasions).

22nd CECE, Conference of European Comparative Endocrinologists, held 24-28 Aug. 2004 in Uppsala. 230 participants.

Naturläkemedel efter Linné (Natural [herbal] products after Linnaeus), Royal Swedish Academy of Sciences, Stockholm, 28 Oct 2008. (Together with Bertil Fredholm)

Symposium "Frontiers of behavioral neuroscience - a tribute to Bengt J. Meyerson", Uppsala University, Dec. 5-6, 2008. 130 participants.

Darwin Symposium Uppsala 25-27 Oct 2009 (Together with Ulf Petterson) 300 participants.

Darwin Symposium, KVA, Stockholm 28 Oct 2009, 120 registered participants.

Future of the Swedish school system, KVA, Stockholm, 11-12 March 2013. >100 participants.

Teacher Competence and the Teaching Profession, KVA, Wenner-Gren Center, Stockholm, 10-13 Sept. 2014. 80 participants.

Co-evolution of receptors and ligands. Wenner-Gren Center, Stockholm, 9-12 Sept. 2015. 80 participants.

Invited speaker at more than 50 following symposia (selected examples):

7. Neuropeptide Y meeting. Organizer: Dr. Janet Allen. University of Cambridge, Cambridge, England, Aug. 9-11, 1993.

9. The biochemistry and molecular biology of pancreatic polypeptide/neuropeptide family. Organizer: Prof. Richard C. Rogers, Ohio State University, Columbus, OH, U. S. A. American Physiological Society, San Diego, Nov. 11-14, 1995.

10. European Society for Comparative Endocrinology. Organizer: Prof. Hubert Vaudry, Rouen, France, Sept. 10-14, 1996.

11. 4th International NPY Conference. Organizer: Prof. Stephen Bloom. London, Oct. 13-14, 1997.

12. 13th International Congress of Comparative Endocrinology. Organizer: Prof. Seiichiro Kawashima. Yokohama, Japan, Nov. 16-21, 1997.

16. 25th Silver Jubilee FEBS Meeting. Organizer: Prof. Julio E. Celis. Copenhagen, Denmark, July 5-10, 1998.

23. 6th International Neuropeptide Y Conference (Plenary lecture). Organizer: Dr. Herbert Herzog. Garvan Institute, Sydney, Australia, April 22-26, 2001.

25. 21st Conference of European Comparative Endocrinologists (Plenary lecture). Organizer: Dr. Rainer Keller, Bonn, Germany, Aug. 26-30, 2002.

27. 15th International Congress of Comparative Endocrinology. Boston May 23-28, 2005.

30. 8th NPY Meeting. St. Petersburg, Florida, USA, April 22-26, 2006.

31. International Symposium on the Evolution of Vertebrates. Organizers: Axel Janke and Ulfur Arnason. Lund University, Lund, Sweden, June 1—3, 2006.

32. Nordic Meeting on G Protein Coupled Receptors - from Molecular Aspects to Novel Therapy. Karolinska Institute, Stockholm, Aug. 17-18, 2006.

33. 23rd Conference of European Comparative Endocrinologists (State-of-the-art lecture). Organizer: Dr. Richard Balment, Manchester, U.K., Aug. 29-Sept. 2, 2006.

34. 9th European Congress of Endocrinology. Organizer: Ezio Ghigo, Budapest, Hungary, Apr. 28-May 2, 2007.

36. 6th International Symposium on Fish Endocrinology (Symposium lecture). Organizer: Hamid Habibi, Calgary. June 22-27, 2008.

37. 24th Conference of European Comparative Endocrinologists (State-of-the-art lecture). Organizer: Mauro Vallarino, Genoa, Sept. 2-6, 2008.

39. 16th International Congress of Comparative Endocrinology (Plenary lecture: the Bargmann-Scharrer lecture). Organizer: Fred Leung. Hong Kong, June 22-26, 2009.

40. Genome evolution and the origin of novel gene functions (Boehringer Ingelheim Fonds International Titisee Conference). Organizers: Axel Meyer and Yves Van de Peer. Titisee, Germany, Oct. 14-18 2009.

41. Meeting of the Society for Integrative and Comparative Biology (SICB). Symposium organizers: Linda Holland and Stacia Sower. Seattle, Jan. 3-7 2010.

43. 7th International Conference of Neuroendocrinology. State-of-the-art lecture: Chromosome duplications in vertebrate neuropeptide evolution. Organizer: Hubert Vaudry, Rouen, July 11-15, 2010.

44. International Narcotics Research Conference. Plenary lecture: Evolution of the opioid system. Malmö, Sweden, July 11-16, 2010.

45. 65th Annual Meeting of the Korean Association of Biological Sciences. Plenary lecture: The impact of genome duplications on funcitonal diversity. Seoul, Korea, Aug. 19, 2010. Organizer: Dr. Sang-Gu Kim, President of the KAOBS.

46. REG PEP 2010, Regulatory Peptides Meeting. Lecture: Evolution of vertebrate neuropeptide receptors. Belfast, UK, Sept. 5-8, 2010.

48. Inaugural meeting of NASCE, the North American Society for Comparative Endocrinology. State-of-the-art lecture: Complex evolution of somatostatin and urotensin II receptors. Ann Arbor, Michigan, July 13-16, 2011. Organizer: Dr. Robert Denver, Univ. of Michigan, Ann Arbor.

52. 15th European Congress of Endocrinology (Symposium lecture). Copenhagen, Denmark, Apr. 27-May 1, 2013.

53. 27th Conference of European Comparative Endocrinologists (State-of-the-art lecture). Organizer: Olivier Kah. Rennes, France. Aug. 25-29, 2014.

54. 7th Summer School Medicinal Chemistry. University of Regensburg. Organizer: Armin Buschauer. Regensburg, Germany, Sept. 17-19, 2014. 

55. Insulin C-peptide. Karolinska Insitute. Organizer: John Wahren. Stockholm, Sept. 14, 2015.

11. Brief description of major discoveries and current research

Brief summaries of my major discoveries and scientific contributions and my ongoing research projects can be found on this page: (in preparation)

12. Teaching [will be updated]

13. Public information about science and medicine

I have worked actively to spread information about scientific discoveries and the scientific approach to lay audiences (radio, TV, newspapers and magazines, both the general public and to teenagers and seniors) and to present the scientific evidence that contradicts pseudoscientific claims such as creationism, parapsychology and homeopathy and other types of alternative medicine, all of which are widely spread misconceptions in our society.

Popular science lectures and panel debates: >120

Radio and TV programmes and interviews: 54

Newspaper/journal interviews: >30

Letters to editors (Swedish: insändare): 38

Popular science articles and book reviews: >50

Study visits: I have organized visits for school classes on multiple occasions, mostly for pupils in grade 9 and “gymnasium” grades 2 and 3.

Contacted by journalists, teachers, pupils and lay persons weekly on issues such as alternative medicine, parapsychology, neurotheology, pseudoscience, and creationism/intelligent design.

Miscellaneous

I have written outline for educational material about mutations for Utbildningsradion, SVT (Swedish Television), 2008.