Scientific Publications

Table of contents:

Thesis

Larhammar, D. Class II transplantation antigens: Molecular Genetic Studies. Acta Universitatis Upsaliensis, Abstracts of Uppsala Dissertations from the Faculty of Medicine, No. 477, ISSN 0345-004X, ISBN 91-554-1491-5 (1983).

Original articles (peer reviewed)

1. Kvist, S., Brégégère, F., Rask, L., Cami, B., Garoff, H., Daniel, F., Wiman, K., Larhammar, D., Abastado, J. P., Gachelin, G., Peterson, P. A., Dobberstein, B., and Kourilsky, P. cDNA clone coding for part of mouse H-2d major histocompatibility antigen. Proc. Natl. Acad. Sci. USA 76, 2772-2776 (1980).

2. Brégégère, F., Abastado, J. P., Kvist, S., Rask, L., Lalanne, J. L., Garoff, H., Cami, B., Wiman, K., Larhammar, D., Peterson, P. A., Gachelin, G., Kourilsky, P., and Dobberstein, B. Structure of C-terminal half of two H-2 antigens from cloned mRNA. Nature 292, 78-81 (1981).

3. Larhammar, D., Wiman, K., Schenning, L., Claesson, L., Gustafsson,K., Peterson, P. A., and Rask, L. Evolutionary relationship between HLA-DR antigen ß chains, HLA-A,B,C antigen subunits and immunoglobulin chains. Scand. J. Immunol. 14, 617-622 (1981).

4. Wiman, K., Larhammar, D., Claesson, L., Gustafsson, K., Schenning, L., Bill, P., Böhme, J., Denaro, M., Dobberstein, B., Hammerling, U., Kvist, S., Servenius, B., Sundelin, J., Peterson, P. A., and Rask, L. Isolation and identification of a cDNA clone corresponding to an HLA-DR antigen ß chain. Proc. Natl. Acad. Sci. USA 79, 1703-1707 (1982).

5. Larhammar, D., Schenning, L., Gustafsson, K., Wiman, K., Claesson, L., Rask, L., and Peterson, P. A. Complete amino acid sequence of an HLA-DR antigen-like ß chain as predicted from the nucleotide sequence: silmilarities with immunoglobulins and HLA-A,B,C antigens. Proc. Natl. Acad. Sci. USA 79, 3687-3691 (1982).

6. Gustafsson, K., Bill, P., Larhammar, D., Wiman, K., Claesson, L., Schenning, L., Servenius, B., Sundelin, J., Rask, L., and Peterson, P. A. Isolation and identification of a cDNA clone coding for an HLA-DR transplantation antigen a chain. Scand. J. Immunol. 16, 303-308 (1982).

7. Larhammar, D., Gustafsson, K., Claesson, L., Bill, P., Wiman, K., Schenning, L., Sundelin, J., Widmark, E., Peterson, P. A., and Rask, L. Alpha chain of HLA-DR transplantation antigen is a member of the same protein superfamily as the immunoglobulins. Cell 30, 153-161 (1982).

8. Gustafsson, K., Wiman, K., Larhammar, D., Rask, L., and Peterson, P. A. Signal sequences distinguish class II histocompatibility antigen ß chains of different loci. Scand. J. Immunol. 19, 91-97 (1983).

9. Hyldig-Nielsen, J. J., Schenning, L., Hammerling, U., Widmark, E., Heldin, E., Lind, P., Servenius, B., Lund, T., Flavell, R. A., Lee, J. S., Trowsdale, J., Schreier, P., Sablitzky, F., Larhammar, D., Peterson, P. A., and Rask, L. The complete nucleotide sequence of the I-E alpha d immune response gene. Nucleic Acids Res. 11, 5055-5071 (1983).

10. Larhammar, D., Hammerling, U., Denaro, M., Lund, T., Flavell, R. A., Rask, L., and Peterson, P. A. Structure of the murine immune response I-Aß locus: sequence of the I-Aß gene and an adjacent ß-chain second domain exon. Cell 34, 179-188 (1983).

11. Larhammar, D., Hyldig-Nielsen, J.J., Servenius, B., Andersson, G., Rask, L., and Peterson, P. A. Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DCß gene. Proc. Natl. Acad. Sci. USA 80, 7313-7317 (1983).

12. Claesson, L., Larhammar, D., Rask, L., and Peterson, P. A. cDNA clone for the human invariant gamma chain of class II MHC antigens and its implication for the protein structure. Proc. Natl. Acad. Sci. USA 80, 7395-7399 (1983).

13. Schenning, L., Larhammar, D., Bill, P., Wiman, K., Jonsson, A.-K., Rask, L., and Peterson, P. A. Both a and ß chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains. EMBO J. 3, 447-452 (1984).

14. Gustafsson, K., Wiman, K., Emmoth, E., Larhammar, D., Böhme, J., Hyldig-Nielsen, J. J., Ronne, H., Rask, L., and Peterson, P. A. Mutations and selection in the generation of class II histocompatibility antigen polymorphism. EMBO J. 3, 1655-1661 (1984).

15. Claesson-Welsh, L., Barker, P. E., Larhammar, D., Rask, L., Ruddle, F. H., and Peterson, P. A. The gene encoding the human class II antigen-associated gamma chain is located on chromosome 5. Immunogenetics 20, 89-93 (1984).

16. Servenius, B., Gustafsson, K., Widmark, E., Emmoth, E., Andersson, G., Larhammar, D., Rask, L., and Peterson, P. A. Molecular map of the human HLA-SB (HLA-DP) region and sequence of an SB a pseudogene. EMBO J. 3, 3209-3214 (1984).

17. Larhammar, D., Servenius, B., Rask, L., and Peterson, P. A. Characterization of an HLA-DRß pseudogene. Proc. Natl. Acad. Sci. USA 82, 1475-1479 (1985).

18. Denaro, M., Gustafsson, K., Larhammar, D., Steinmetz, M., Peterson, P. A., and Rask, L. Murine MHC class II gene Eß2 is closely related to Eß and to HLA-DRß. Immunogenetics 21, 613-616 (1985).

19. Larhammar, D., Hammerling, U., Rask, L., and Peterson, P. A. Sequence of gene and cDNA encoding murine major histocompatibility complex class II gene Aß2. J. Biol. Chem. 260, 14111-14119 (1985).

20. Sundelin, J., Laurent, B. C., Anundi, H., Trägårdh, L., Larhammar, D., Björk, L., Eriksson, U., Åkerström, B., Jones, A., Newcomer, M., Peterson, P. A., and Rask, L. Amino acid sequence homologies between rabbit, rat and human serum retinol-binding proteins. J. Biol. Chem. 260, 6472-6480 (1985).

21. Fernandez, C., Larhammar, D., Servenius,B., Rask, L., and Peterson, P. A. Spontaneous insertions into cosmid vector: a warning. Gene 42, 215-219 (1986).

22. O'Sullivan, D. M., Larhammar, D., Wilson, M. C., Peterson, P. A., and Quaranta, V. Structure of the human Ia-associated invariant (gamma) chain gene and identification of 5' sequences shared with MHC class II genes. Proc. Natl. Acad. Sci. USA 83, 448l4-4488 (1986).

23. Guy, K., Meehan, R. R., Dewar, A. E., and Larhammar, D. Expression of MHC class II antigens in human B-cell leukemia, and increased levels of class II antigens and DR-specific mRNA after stimulation with 12-O-tetradecanoyl phorbol-13-acetate. Immunology 57, 181-188 (1986).

24. Gustafsson, K., Widmark, E., Jonsson, A.-K., Servenius, B., Sachs, D. H., Larhammar, D., Peterson, P. A., and Rask, L. Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes. J. Biol. Chem. 262, 8778-8786 (1987).

25. Andersson, G., Larhammar, D., Widmark, E., Servenius, B., Rask, L., and Peterson, P. A. Class II genes of the major histocompatibility complex. Organization and evolutionary relationship of the DRß genes. J. Biol. Chem. 262, 8748-8758 (1987).

26. Jonsson, A.-K., Hyldig-Nielsen, J. J., Servenius, B., Larhammar, D., Andersson, G., Jörgensen, F., Peterson, P. A., and Rask, L. Class II genes of the major histocompatibility complex. Comparisons of the DQ and DX a and ß genes. J. Biol. Chem. 262, 8767-8777 (1987).

27. Ebendal, T., Larhammar, D., and Persson, H. Structure and expression of the chicken ß nerve growth factor gene. EMBO J. 5, 1481-1487 (1986).

28. Larhammar, D., Ericsson, A., and Persson, H. Structure and expression of the rat neuropeptide-Y gene. Proc. Natl. Acad. Sci. USA 84, 2068-2072 (1987).

29. Ericsson, A., Schalling, M., McIntyre, K. R., Lundberg, J. M., Larhammar, D., Seroogy, K., Hökfelt, T., and Persson, H. Detection of neuropeptide Y and its mRNA in megakaryocytes: Enhanced levels in certain autoimmune mice. Proc. Natl. Acad. Sci. USA 84, 5585-5589 (1987).

30. Schalling, M., Seroogy, K., Hökfelt, T., Chai, S. Y., Hallman, H., Persson, H., Larhammar, D., Ericsson, A., Terenius, L., Massoulie, J., and Goldstein, M. Neuropeptide Y in the rat adrenal gland - immunohistochemical and in situ-hybridization studies. Neuroscience 24, 337-349 (1988).

31. Whittemore, S. R., Persson, H., Ebendal, T., Lärkfors, L., Larhammar, D., Ericsson, A. Structure and expression of ß-nerve growth factor in the rat central nervous system. In "Cellular and Molecular Aspects of Neural Development and Regeneration", NATO Adv. Study Inst. Series. Ed.: Gorio, A., Perez-Polo, J. R., de Vellis, J., and Haber, B., Springer-Verlag, Heidelberg, Vol. H22, 245-256 (1988).

32. Whittemore, S. R., Friedman, P. L., Larhammar, D., Persson, H., Gonzalez-Carvajal, M., and Holets, V. R. Rat ß-nerve growth factor sequence and site of synthesis in the adult hippocampus. J. Neurosci. Res. 20, 403-410 (1988).

33. Widmark, E., Ronne, H., Hammerling, U., Servenius, B., Larhammar, D., Gustafsson, K., Böhme, J., Peterson, P. A., and Rask, L. Family relationships of murine major histocompatibility complex class I genes: Sequence of the T2Aa pseudogene, a member of gene family 3. J. Biol. Chem. 263, 7055-7059 (1988).

34. Ebendal, T., Persson, H., Larhammar, D., Lundströmer, K., and Olson, L. Characterization of antibodies to synthetic nerve growth factor (NGF)- and proNGF-peptides. J. Neurosci. Res. 22, 223-240 (1989).

35. Larhammar, D. and Milner, R. J. Phylogenetic relationship of birds with crocodiles and mammals as deduced from protein sequences. Mol. Biol. Evol. 6, 693-696 (1989).

36. Feinstein, D. L. and Larhammar, D. Identification of a conserved protein motif in a group of growth factor receptors. FEBS Lett. 272, 7-11 (1990).

37. Catsicas, S., Larhammar, D., Blomqvist, A. G., Sanna, P. P., Milner, R. J., and Wilson, M. C. Expression of a conserved cell-type-specific protein in nerve terminals coincides with synaptogenesis. Proc. Natl. Acad. Sci. USA 88, 785-789 (1991).

38. Wahlestedt, C., Karoum, F., Jaskiw, G., Larhammar, D., Ekman, R., and Reis, D. J. Cocaine-induced reduction of brain NPY synthesis dependent on medial prefrontal cortex. Proc. Natl. Acad. Sci. USA 88, 2078-2982 (1991).

39. Andersson, G. and Larhammar, D. Letter to the editor. Immunogenetics 34, 66-67 (1991).

40. Blomqvist, A. G., Söderberg, C., Lundell, I., Milner, R. J., and Larhammar, D. Strong evolutionary conservation of neuropeptide Y (NPY); sequences of chicken, goldfish, and Torpedo marmorata DNA clones. Proc. Natl. Acad. Sci. USA. 89, 2350-2354 (1992).

41. Pieribone, V. A., Brodin, L., Friberg, K., Dahlstrand, J., Söderberg, C., Larhammar, D., and Hökfelt, T. Differential expression of mRNAs for neuropeptide Y-related peptides in rat nervous tissues: possible evolutionary conservation. J. Neurosci. 12, 3361-3371 (1992).

42. Larhammar, D., Blomqvist, A. G., Yee, F., Jazin, E., Yoo, H., and Wahlestedt, C. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. J. Biol. Chem. 267, 10935-10938 (1992).

43. Chatzidimitriou-Dreismann, C. A. and Larhammar, D. Long-range correlations in DNA. (Scientific Correspondence) Nature 361, 212-213 (1993).

44. Peng, C., Humphries, S., Peter, R. E., Rivier, J. E., Blomqvist, A. G., and Larhammar, D. Actions of goldfish neuropeptide Y on the secretion of growth hormone and gonadotropin-II in the goldfish. Gen. Comp. Endocrinol. 90, 306-317 (1993).

45. Risinger, C. and Larhammar, D. Multiple loci for synapse protein SNAP-25 in the tetraploid goldfish. Proc. Natl. Acad. Sci. USA 90, 10598-10602 (1993).

46. Jazin, E., Yoo, H., Blomqvist, A. G., Yee, F., Weng, G., Walker, M. W., Salon, J., Larhammar, D., and Wahlestedt, C. A proposed bovine neuropeptide Y (NPY) receptor and its human homologue do not confer NPY binding sites nor NPY responsiveness on transfected cells. Regul. Peptides 47, 247-258 (1993).

47. Jazin, E., Zhang, X., Söderström, S., Williams, R., Hökfelt, T., Ebendal, T., and Larhammar, D. Expression of peptide YY and the NPY/PYY receptor of the Y1 subtype in dorsal root ganglia during rat embryogenesis. Developm. Brain Res. 76, 105-113 (1993).

48. Risinger, C., Blomqvist, A. G., Lundell, I., Lambertsson, A., Nässel, D., Pieribone, V. A., Brodin, L., and Larhammar, D. Evolutionary conservation of synapse protein SNAP-25 shown by Drosophila and Torpedo cDNA clones. J. Biol. Chem. 268, 24408-24414 (1993).

49. Matre, V., Karlsen, H. E., Wright, M. S., Lundell, I., Fjeldheim, Å. K., Gabrielsen, O. S., Larhammar, D., and Gautvik, K. M. Molecular cloning of a functional human thyrotropin-releasing hormone receptor. Biochem. Biophys. Res. Comm. 195, 179-185 (1993).

50. Larhammar, D. and Chatzidimitriou-Dreismann, C. A. Biological origins of long-range correlations and compositional variations in DNA. Nucleic Acids Res. 21, 5167-5170 (1993).

51. Söderberg, C., Pieribone, V. A., Dahlstrand, J., Brodin, L., and Larhammar, D. Neuropeptide role of both neuropeptide Y and peptide YY in vertebrates suggested by abundant expression of both mRNAs in a cyclostome brain. J. Neurosci. Res. 37, 633-640 (1994).

52. Andersson, G., Andersson, L., Larhammar, D., Rask, L., and Sigurdadottir, S. Genetic locus assignment of HLA DRB genes. Immunology Today 15, 58-61 (1994).

53. Chatzidimitriou-Dreismann, C. A., Streffer, R. M. F., and Larhammar, D. Variations in base pair composition and associated long-range correlations in DNA sequences - computer simulation results. Biochim. Biophys. Acta 1217, 181-187 (1994).

54. Blomqvist, A., Hermanson, O., Ericson, H., and Larhammar D. Activation of a bulbospinal opioidergic projection by pain stimuli in the awake rat. NeuroReport 5, 461-464 (1994).

55. Peng, C., Gallin, W., Peter, R. E., Blomqvist, A. G., and Larhammar, D. Neuropeptide Y gene expression in the goldfish brain: distribution and regulation by ovarian steroids. Endocrinology 134, 1095-1103 (1994).

56. Larhammar, D. and Risinger, C. Molecular genetic aspects of tetraploidy in the common carp, Cyprinus carpio. Mol. Phylogenet. Evol. 3, 59-68 (1994).

57. Larhammar, D. Lack of experimental support for Kuznetsov's criticism of biological evolution. (Letter to the Editor.) Intern. J. Neurosci. 77, 199-201 (1994).

58. Chatzidimitriou-Dreismann, C. A., Streffer, R. M. F., and Larhammar, D. Quantitative test of long-range correlations and compositional fluctuations in DNA sequences. Eur. J. Biochem. 224, 365-371 (1994).

59. Larhammar, D. and Risinger, C. Why so few pseudogenes in tetraploid species such as Xenopus laevis, salmon, trout, goldfish and carp? Trends Genet. 10, 418-419 (1994).

60. Arvidsson, A.-K., Svensson, A.-C., Widmark, E., Andersson, G., Rask, L, and Larhammar, D. Characterization of three separated exons in the HLA class II DR region of the human major histocompatibility complex. Human Immunol. 42, 254-264 (1995).

61. Blomqvist, A. G., Roubos, E. W., Larhammar, D., and Martens, G. J. M. Cloning and sequence analysis of a neuropeptide Y/peptide YY receptor Y1 from Xenopus laevis. Biochim. Biophys. Acta 1261, 439-441 (1995).

62. Lundell, I., Blomqvist, A. G., Berglund, M. M., Schober, D. A., Johnson, D., Statnick, M. A., Gadski, R. A., Gehlert, D. R., and Larhammar, D. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J. Biol. Chem. 270, 29123-29128 (1995).

63. Lundell, I., Statnick, M. A., Johnson, D., Schober, D. A., Starbäck, P., Gehlert, D. R., and Larhammar, D. The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous human receptor. Proc. Natl. Acad. Sci. USA 93, 5111-5115 (1996).

64. Chatzidimitriou-Dreismann, C. A., Streffer, R. M. F., and Larhammar, D. Lack of biological significance in the 'linguistic features' of noncoding DNA - a quantitative analysis. Nucl. Acids Res. 24, 1676-1681 (1996).

65. Gehlert, D. R., Schober, D. A., Beavers, L., Gadski, R., Hoffman, J. A., Smiley, David L., Chance, R. E., Lundell, I., and Larhammar, D. Characterization of the peptide binding requirements for the cloned human pancreatic polypeptide preferring (PP1) receptor. Mol. Pharmacol. 50, 112-118 (1996).

66. Gehlert, D. R. Gackenheimer, S. L., Schober, D. A., Beavers, L., Gadski, R. Burnett, J. P., Mayne, N., Lundell, I., and Larhammar, D. The neuropeptide Y Y1 receptor selective radioligand, [125I][Leu31,Pro34]peptide YY, is also a high affinity radioligand for human pancreatic polypeptide 1 receptors. Eur. J. Pharmacol. 318, 485-490 (1996).

67. Yuan, P.-Q., Grånäs, C., Källström, L., Yu, J., Huhman, K., Larhammar, D., Albers, H. E., and Johnson, A. E. Differential distribution of the GAD65 and GAD67 mRNAs in limbic and motor subregions of the entopeduncular nucleus in the rat. Neuroscience 78, 87-97 (1997).

68. Risinger, C., Deitcher, D., Lundell, I., Schwarz, T. L., and Larhammar, D. Complex gene organization of synaptic protein SNAP-25 in Drosophila melanogaster. Gene 194, 169-177 (1997).

69. Gehlert, D.R., Schober, D.A. , Gackenheimer, S.L., Beavers, L., Johnson, D., Gadski, R., Lundell, I., and Larhammar, D. [125I]-Leu31-Pro34-PYY is a high affinity radioligand for rat PP1 and Y1 receptors: Evidence for heterogeneity in pancreatic polypeptide receptors. Peptides 18, 397-401 (1997).

70. Lundell, I., Berglund, M. M., Starbäck, P., Salaneck, E., Gehlert, D. R., and Larhammar, D. Cloning and characterization of a novel neuropeptide Y receptor subtype in the zebrafish. DNA and Cell Biol. 16, 1357-1363 (1997).

71. Ringvall, M., Berglund, M. M., and Larhammar, D. Multiplicity of Neuropeptide Y Receptors: Cloning of a third distinct subtype in the Zebrafish. Biochem. Biophys. Res. Comm. 241, 749-755 (1997).

72. Jazin, E. E., Söderström, S., Ebendal, T., and Larhammar, D. Embryonic expression of the rat homologue of the fusin/CXCR-4 HIV-1 co-receptor. Neuroimmunology 79, 148-154 (1997)

73. Postlethwait, J. H., Yan, Y.-L., Gates, M., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E. S., Force, A., Gong, Z., Goutel, C., Fritz, A., Kelsh, R., Knapi, E., Liao, E., Paw, B., Ransom, D., Singer, A., Thomson, M., Abduljabbar, T. S., Yelick, P., Beier, D., Joly, J.-S., Larhammar, D., Rosa, F., Westerfield, M., Zon, L. I., Johnson, S. L., and Talbot, W. S. (Also Ekker, M.) Vertebrate genome evolution and the zebrafish gene map. Nature Genetics 18, 345-349 (1998).

74. Törnsten, A. Wraith, A., Larhammar, D., and Chowdhary, B. FISH mapping of the porcine NPY5 gene to chromosome 8p11. Mammalian Genome 9, 262-263 (1998).

75. Hermanson, O., Larhammar, D., and Blomqvist, A. Preprocholecystokinin mRNA-expressing neurons in the rat parabrachial nucleus: Subnuclear localization, efferent projection and expression of nociceptive-related intracellular signaling substances. J. Comp. Neurol. 400, 255-270 (1998).

76. Parker, D., Söderberg, C., Zotova, E., Shupliakov, O., Langel, Ü., Bartfai, T., Larhammar, D., Brodin, L., and Grillner, S. Co-localized neuropeptide Y and GABA have complementary presynaptic effects on sensory synapticnsmission. J. Neuroscience 10, 2856-2870 (1998).

77. Grånäs, C., Nordvall, G., and Larhammar, D. Site-directed mutagenesis of the human 5-hydroxytryptamine1B receptor. Eur. J. Pharmacol. 349, 367-375 (1998).

78. Grånäs, C., Nordvall, G., and Larhammar, D. Mutagenesis of the human 5-HT1B receptor; differences from the closely related 5-HT1A receptor and identification of the role for residue F331 in signal transduction. J. Rec. Signal Transduction Res. 18, 225-241 (1998).

79. Sharma, P., Holmberg, S. K. S., Eriksson, H., Beck-Sickinger, A. G., Grundemar, L., and Larhammar, D. Cloning and functional expression of the guinea pig neuropeptide Y Y2 receptor. Regul. Peptides 75-76, 23-28 (1998).

80. Eriksson, H., Berglund, M. M., Holmberg, S. K. S., Kahl, U., Gehlert, D. R., and Larhammar, D. The cloned guinea pig pancreatic polypeptide receptor Y4 resembles more the human Y4 than does the rat Y4. Regul. Peptides 75-76, 29-37 (1998).

81. Arvidsson, A.-K., Wraith, A., Jönsson-Rylander, A.-C., and Larhammar, D. Cloning of a neuropeptide Y/peptide YY receptor from the Atlantic cod: the Yb receptor. Regul. Peptides 75-76, 39-43 (1998).

82. Risinger, C., Salaneck, E., Söderberg, C., Gates, M., Postlethwait, J. H., and Larhammar, D. Cloning of two loci for synapse protein Snap25 in zebrafish: Comparison of paralogous linkage groups suggests loss of one locus in the mammalian lineage. J. Neuroscience Res. 54, 563-573 (1998).

83. Johard, H. A. D., Risinger, C., Nässel, D. R., and Larhammar, D. The highly conserved synapse protein SNAP-25 displays sequence variability in the cockroach Leucophaea maderae. Comp. Biochem. Physiol. 122, 63-68 (1999).

84. Owe-Larsson, B., Berglund, M. M., Kristensson, K., Garoff, H., Larhammar, D., Brodin, L., and Löw, P. Inhibition of synaptic transmission in hippocampal neurons by overexpression of SNAP-25 with the Semliki Forest virus vector. Eur. J. Neurosci. 11, 1981-1987 (1999).

85. Starbäck, P., Lundell, I., Fredriksson, R., Berglund, M. M., Yan, Y.-L., Wraith, A., Söderberg, C., Postlethwait, J. H., and Larhammar, D. Neuropeptide Y receptor subtype with unique properties cloned in the zebrafish: the zYa receptor. Mol. Brain Res. 70, 242-252 (1999).

86. Berglund, M. M., Holmberg, S. K. S., Eriksson, H., Gedda, K., Maffrand, J.-P., Serradeil-Le Gal, C., Chhajlani, V., Grundemar, L., and Larhammar, D. The cloned guinea pig neuropeptide Y receptor Y1 conforms to other mammalian Y1 receptors. Peptides 20, 1043-1053 (1999).

87. Sharma, P., Arvidsson, A.-K., Wraith, A., Beck-Sickinger, A., Jönsson-Rylander, A.-C., and Larhammar, D. Characterization of the cloned Atlantic cod neuropeptide Y-Yb receptor: peptide binding requirements distinct from known mammalian Y receptors. Gen. Comp. Endocrinol. 115, 422-428 (1999).

88. Cerdá-Reverter, J. M., Martínez-Rodríguez, G., Zanuy, S., Carrillo, M., and Larhammar, D. Cloning the neuropeptide Y exon 2 from sea bass (Dicentrarchus labrax). Comp. Biochem. Physiol. 123, 181-186 (1999).

89. Grånäs, C. and Larhammar, D. Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT1B receptor. Eur. J. Pharmacol. 380, 171-181 (1999).

90. Löw, P., Norlin, T., Risinger, C., Larhammar, D., Pieribone, V. A., Shupliakov, O., and Brodin, L. Effects of SNAP-25 antibodies on neurotransmitter release and synaptic vesicle organization in a vertebrate giant synapse. Eur. J. Cell Biol. 78, 787-793 (1999).

91. Wraith, A., Törnsten, A., Chardon, P., Harbitz, I., Chowdhary, B.P., Andersson, L., Lundin, L.-G., and Larhammar, D. Evolution of the neuropeptide Y receptor family: Gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig. Genome Res. 10, 302-310 (2000).

92. Söderberg, C., Wraith, A., Ringvall, M., Yan, Y.-L., Postlethwait, J., Brodin, L., and Larhammar, D. Zebrafish genes for neuropeptide Y and peptide YY reveal origin by chromosome duplication from an ancestral gene linked to the homeobox cluster. J. Neurochem. 75, 908-918 (2000).

93. Berglund, M. M., Lundell, I., Cabrele, C., Serradeil-Le Gal, C., Beck-Sickinger, A. G., and Larhammar, D. Binding properties of three neuropeptide Y receptor subtypes from zebrafish - comparison with mammalian Y1 receptors. Biochem. Pharmacology 60, 1815-1822 (2000).

94. Cerdá-Reverter, J. M., Martínez-Rodríguez, G., Zanuy, S., Carrillo, M., and Larhammar, D. Molecular evolution of the neuropeptide Y (NPY) family of peptides: cloning of NPY-related peptides from the sea bass(Dicentrarchus labrax).Regul. Peptides 95, 25-34 (2000).

95. Starbäck, P., Wraith, A., Eriksson, H., and Larhammar, D. Neuropeptide Y receptor gene y6: multiple deaths or resurrections? Biochem. Biophys. Res. Comm. 277, 264-269 (2000).

96. Salaneck, E., Holmberg, S. K. S., Berglund, M. M., Boswell, T., and Larhammar, D. Chicken neuropeptide Y receptor Y2: Structural and pharmacological differences to mammalian Y2. FEBS Lett. 484, 229-234 (2000).

97. Berglund, M. M., Lundell, I., Eriksson, H., Söll, R., Beck-Sickinger, A., G., and Larhammar, D. Structure-activity analyses of the neuropeptide Y-family receptor Y4; studies of the human, rat, and the guinea pig receptors using NPY analogues and two distinct radioligands. Peptides 22, 351-356 (2001).

98. Lundell, I., Eriksson, H., Marklund, U., and Larhammar, D. Cloning and characterization of the guinea pig neuropeptide Y receptor Y5. Peptides 22, 357-363 (2001).

99. Berglund, M. M., Saar, K., Langel, Ü., and Larhammar, D. Binding of chimeric NPY/galanin peptides M32 and M242 to cloned neuropeptide Y receptor subtypes Y1, Y2, and Y4. Neuropeptides 35, 148-153 (2001).

100. Grånäs, C., Nordquist, J., Mohell, N., and Larhammar, D. Mutations in the 5-HT1B receptor change the ability to adopt the G protein coupled conformation and the affinity of 5-HT for the uncoupled conformation. Eur. J. Pharmacol. 421, 69-76 (2001).

101. Hallbeck, M., Larhammar, D., and Blomqvist, A. Neuropeptide expression in rat paraventricular hypothalamic neurons that project to the spinal cord. J. Comp. Neurol. 433, 222-238 (2001).

102. Söll, R. M., Dinger, M. C., Lundell, I., Larhammar, D., and Beck-Sickinger, A. G. Novel analogs of neuropeptide Y with preference for the Y1-receptor. Eur. J. Biochem 268, 2828-2837 (2001).

103. Johard, H. A. D., Muren, J. E., Nichols, R., Larhammar, D., and Nässel, D. R. A putative tachykinin receptor in the cockroach: molecular cloning and analysis of tissue expression by means of antisera to portions of the receptor protein. Brain Res. 919, 94-105 (2001).

104. Salaneck, E., Fredriksson, R., Larson, E. T., Conlon, J. M., and Larhammar, D. A neuropeptide Y receptor Y1-like gene from an agnathan, the European river lamprey: a pontential ancestral gene. Eur. J. Biochem. 268, 6146-6154 (2001).

105. Lagerström-Fermér, M., Larhammar, D., Johnsen, E., and Landegren, U. Comparative genomics by capture PCR. Genomics 79, 442-446 (2002).

106. Holmberg, S. K. S., Mikko, S., Boswell, T., Zoorob, R., and Larhammar, D. Pharmacological characterization of cloned chicken neuropeptide Y receptors Y1 and Y5. J. Neurochem. 81, 462-471 (2002).

107. Galas, L., Tonon, M.-C., Beaujean, D., Fredriksson, R., Larhammar, D., Lihrmann, I., Jegou, S., Fournier, A., Chartrel, N., and Vaudry, H. Neuropeptide Y inhibits spontaneous a-melanocyte-stimulating hormone (a-MSH) secretion via a Y1 receptor in frog melanotrope cells. Endocrinology 143, 1686-1694 (2002).

108. Beaujean, D., Do-Rego, J.-L., Galas, L., Mensah-Nyagan, A. G., Fredriksson, R., Larhammar, D., Fournier, A., Luu-The, V., Pelletier, G., and Vaudry, H. Neuropeptide Y inhibits the biosynthesis of sulfated neurosteroids in the hypothalamus through activation of Y1 receptors. Endocrinology 143, 1950-1963 (2002).

109. Schiöth, H. B., Bouifrouri, A. A., Rudzish, R., Muceniece, R., Watanobe, H., Wikberg, J. E. S., and Larhammar, D. Pharmacological comparison of rat and human melanocortin 3 and 4 receptors in vitro. Regul. Peptides 106, 7-12 (2002).

110. Lecklin, A., Lundell, I., Paananen, L., Wikberg, J. E. S., Männistö, P., and Larhammar, D. Receptor subtypes Y1 and Y5 mediate neuropeptide Y-induced feeding in the guinea-pig. Br. J. Pharmacol. 135, 2029-2037 (2002).

111. Lundell, I., Boswell, T., and Larhammar, D. Chicken neuropeptide Y-family receptor Y4; a receptor with equal affinity for pancreatic polypeptide, neuropeptide Y and peptide YY. J. Mol. Endocrinol. 28, 225-235 (2002).

112. Berglund, M. M., Fredriksson, R., Salaneck, E., and Larhammar, D. Reciprocal mutations of neuropeptide Y receptor Y2 in human and chicken identify amino acids important for antagonist binding. FEBS Lett. 518, 5-9 (2002).

113. Ringholm, A., Fredriksson, R., Poliakova, N., Yan, Y.-L., Postlethwait, J. H., Larhammar, D., and Schiöth, H. B. One melanocortin-4 and two melanocortin-5 receptors from zebrafish show remarkable conservation in structure and pharmacology. J. Neurochem. 82, 6-18 (2002).

114. Dunér, T., Conlon, J. M., Kukkonen, J. P., Åkerman, K. E. O., Yan, Y.-L., Postlethwait, J. H., and Larhammar, D. Cloning, structural characterization and functional expression of a zebrafish bradykinin B2-related receptor. Biochem. J. 364, 817-824 (2002).

115. Shahbazi, F., Holmgren, S., Larhammar, D., and Jensen, J. Neuropeptide Y effects on vasorelaxation and intestinal contraction in the Atlantic cod, Gadus morhua. Am. J. Physiol. 282, R1414-1421 (2002).

116. Larhammar, D., Lundin, L.-G., and Hallböök, F. The human Hox-bearing chromosome regions did arise by block or chromosome (or even genome) duplications. Genome Research 12, 1910-1920 (2002).

117. Ringholm, A., Klovins, J., Fredriksson, R., Poliakova, N., Larson, E. T., Kukkonen, J. P., Larhammar, D., and Schiöth, H. B. Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central MC system. Eur. J. Biochem. 270, 213-221 (2003).

118. Larson, E. T., Fredriksson, R., Johansson, S. R. T., and Larhammar, D. Cloning, pharmacology and distribution of the neuropeptide Y receptor Yb in rainbow trout. Peptides 24, 385-395 (2003).

119. Schiöth, H. B., Raudsepp, T., Ringholm, A., Fredriksson, R., Takeuchi, S., Larhammar, D., and Chowdhary, B. P. Remarkable synteny conservation of melanocortin receptors in chicken, human and other vertebrates. Genomics 81, 504-509 (2003).

120. Salaneck, E. W., Ardell, D. H., Larson, E. T., and Larhammar, D. Three neuropeptide Y receptors in the spiny dogfish, Squalus acanthias, support chromosome doublings in early vertebrate evolution. Mol. Biol. Evol. 20, 1271-1280 (2003).

121. Lecklin, A., Lundell, I., Salmela, S., Männistö, P. T., Beck-Sickinger, A. G., and Larhammar, D. Agonists for neuropeptide Y receptors Y1 and Y5 stimulate different phases of feeding in guinea pigs. Br. J. Pharmacol. 139, 1433-1440 (2003).

122. Nordström, K., Scholten, I., Nordström, J., Larhammar, D., and Miller, D. Mutational analysis of the Acropora millepora PaxD paired domain highlights the importance of the linker region for DNA binding. Gene 320, 81-87 (2003).

123. Fredriksson, R., Larson, E. T., Yan, Y.-L., Postlethwait, J. H., and Larhammar, D. Novel neuropeptide Y Y2-like receptor subtype in zebrafish and frogs supports early vertebrate chromosome duplications. J. Mol. Evol. 58, 106-114 (2004).

124. Ruuskanen, J., Xhaard, H., Marjamäki, A., Salaneck, E., Salminen, T., Yan, Y.-Li., Postlethwait, J. H., Johnson, M. S., Larhammar, D., and Scheinin, M. Early emergence of multiple a2-adrenergic receptor subtypes by chromosomal duplications as revealed by cloning and mapping of five receptor subtype genes in the zebrafish (Danio rerio) - identification of a duplicated fourth a2-adrenergic receptor subtype. Mol. Biol. Evol. 21, 14-28 (2004).

125. Holmberg, S. K. S., Johnson, A. E., Bergqvist, C., Källström, L., and Larhammar, D. Localization of neuropeptide Y receptor Y5 mRNA in the guinea pig brain. Regul. Peptides 117, 61-67 (2004).

126. Nordström, K., Larsson, T. A., and Larhammar, D. Extensive duplications of phototransduction genes in early vertebrate evolution correlate with block (chromosome) duplications. Genomics 83, 852-872 (2004).

127. Haitina, T., Klovins, J., Andersson, J., Fredriksson, R., Lagerström, M. C., Larhammar, D., Larson, E. T., Schioth, H. B. Cloning, tissue distribution, pharmacology and 3D modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes. Biochem. J. 380, 475-486 (2004).

128. Bromée, T., Kukkonen, J., Andersson, P., Conlon, J. M., and Larhammar, D. Pharmacological characterization of ligand-receptor interactions at the zebrafish bradykinin receptor. Br. J. Pharmacol. 144, 11-16 (2005).

129. Granqvist, P., Fredrikson, M., Unge, P., Hagenfeldt, A., Valind, S., Larhammar, D., and Larsson, M. Sensed presence and mystical experiences are predicted by suggestibility, not by the application of transcranial weak complex magnetic fields. Neurosci. Lett. 379, 1-6 (2005).

See also: Persinger, M. A. and Koren, S. A. A response to Granqvist et al. "Sensed presence and mystical experiences are predicted by suggestibility, not by the application of transcranial weak magnetic fields". Neurosci. Lett. 380, 346-347 (2005).

130. Larsson, M., Larhammar, D., Fredrikson, M., and Granqvist, P. Reply to M.A. Persinger and S. A. Koren's response to Granqvist et al. "Sensed presence and mystical experiences are predicted by suggestibility, not by the application of transcranial weak magnetic fields". Neurosci. Lett. 380, 348-50 (2005).

131. Fredriksson, R., Sjödin, P., Larson, E. T., Conlon, J. M., and Larhammar, D. Cloning and characterization of a zebrafish Y2 receptor. Regul. Pept. 133, 32-40 (2006).

132. Sjödin,P., Holmberg, S. K. S., Åkerberg, H., Berglund, M. M., Mohell, N., and Larhammar, D. Re-evaluation of receptor-ligand interactions of the human neuropeptide Y receptor Y1; a site-directed mutagenesis study. Biochem. J. 393, 161-169 (2006).

133. Larsson, T. A., Larson, E. T., Fredriksson, R., Conlon, J. M., and Larhammar, D. Characterization of NPY receptor subtypes Y2 and Y7 in rainbow trout Oncorhynchus mykiss. Peptides 27, 1320-1327 (2006).

134. Bromée, T., Venkatesh, B., Brenner, S., Postlethwait, J. H., Yan, Y.-L., and Larhammar, D. Uneven evolutionary rates of bradykinin B1 and B2 receptors in vertebrate lineages. Gene 373, 100-108 (2006).

135. Bromée, T.*, Sjödin, P.*, Fredriksson, R., Boswell, T., Larsson, T. A., Salaneck, E., Zoorob, R., Mohell, N., and Larhammar, D. Neuropeptide Y-family receptors Y6 and Y7 in chicken: Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region. FEBS J. 273, 2048-2063 (2006). *These authors contributed equally.

136. Larsson, T. A., Larson, E. T., and Larhammar, D. Cloning and sequence analysis of the neuropeptide Y receptors Y5 and Y6 in the Coelacanth Latimeria chalumnae. Gen. Comp. Endocrinol. 150, 337-342 (2007).

137. Sundström, G., Larsson, T. A., Brenner, S., Venkatesh, B., and Larhammar, D. Evolution of the neuropeptide Y family: new genes by chromosome duplications in early vertebrates and in teleost fishes. Gen. Comp. Endocrinol. 155, 705-716 (2008). PMID: 17950734.

138. Salaneck, E., Larson, E.T., Larsson, T.A. & Larhammar, D. Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization. Gene 409, 61-71, (2008). PMID: 18191918.

139. Larsson, T. A., Olsson, F., Sundström, G., Lundin, L. G., Brenner, S., Venkatesh, B., and Larhammar, D. Early vertebrate chromosome duplications and the evolution of the neuropeptide Y receptor gene regions. BMC Evol. Biol. 8, 184- (2008). PMID: 18578868.

140. Sundström, G., Larsson, T. A., and Larhammar, D. Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters. BMC Evolutionary Biology 2008, 8:254 (2008). PMID: 18803835.

141. Dreborg, S., Sundström, G., Larsson, T. A., and Larhammar, D. Evolution of vertebrate opioid receptors. Proc. Natl. Acad. Sci. USA 105, 15487-15492 (2008). PMID: 18832151.

142. Larsson, T. A. Tay, B.-H., Sundström, G., Fredriksson, R., Brenner, S., Larhammar, D., and Venkatesh, B. Neuropeptide Y-family peptides and receptors in the elephant shark, Callorhinchus milii confirm gene duplications before the gnathostome radiation. Genomics 93, 254-260 (2009). PMID: 18977429.

143. Schjolden, J., Schiöth, H. B., Larhammar, D., Winberg, S., and Larson, E. T. Melanocortin peptides affect the motivation to feed in rainbow trout (Oncorhynchus mykiss). Gen. Comp. Endocrinol. 160, 134-138 (2009). PMID: 19027741.

144. Gruber, K., Fan, W., Åkerberg, H., Larhammar, D., Chee, M. J. S., Colmers, W. F., and Cone, R. D. Neuropeptide Y and gamma-melanocyte stimulating hormone (a-MSH) share a common pressor mechanism of action. Endocrine 35, 312-324 (2009). PMID: 19363600.

145. Blomkvist, J., Taube, A., and Larhammar, D. Perspective on roseroot (Rhodiola rosea) studies. Planta Medica 75, 1-4 (2009). PMID: 19468971.

146. Larhammar, D., Nordström, K., and Larsson, T. A. Evolution of vertebrate rod and cone phototransduction genes. Phil. Trans. R. Soc. B. 364, 2867-2880 (2009). PMID: 19720650.

147. Åkerberg, H., Meyerson, B., Sallander, M., Lagerstedt, A.-S., Hedhammar, Å., and Larhammar, D. Peripheral administration of pancreatic polypeptide inhibits components of food-intake behavior in dogs. Peptides 31, 1055-1061 (2010). PMID: 20338207.

148. Sundström, G., Dreborg, S., and Larhammar, D. Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. PLoS One, May 6; 5(5):e10512 (2010). PMID: 20463905.

149. Åkerberg, H.*, Fällmar, H.*, Sjödin, P., Boukharta, L., Gutiérrez-de-Terán, H., Lundell, I., Mohell, N., and Larhammar, D. Mutagenesis of human neuropeptide Y/peptide YY receptor Y2 reveals additional differences to Y1 in interactions with highly conserved ligand positions. (*These authors contributed equally.) Regulatory Peptides 163, 120-129 (2010). PMID: 20471432.

150. Widmark, J., Sundström, G., Ocampo Daza, D., and Larhammar, D. Differential evolution of voltage-gated sodium channels in tetrapods and teleost fishes. Mol. Biol. Evol. 28, 859-871 (2011). PMID: 20924084.

151. Lundell, I., Rabe, N., Jonsson, A.K., and Larhammar, D. Internalization studies of chimeric neuropeptide Y receptors Y1 and Y2 suggest complex interactions between cytoplasmic domains. Regulatory Peptides 168, 50-58 (2011). PMID: 21466826.

152. Ocampo Daza, D., Sundström, G., Bergqvist, C. A., Cuan, C., and Larhammar, D. Evolution of the insulin-like growth factor binding protein (IGFBP) family. Endocrinology 152, 2278-2289 (2011). Epub 19 Apr 2011. PMID: 21505050.

153. Fällmar, H., Åkerberg, H., Gutiérrez-de-Terán, H., Lundell, I., Mohell, N., and Larhammar, D. Identification of positions in the human neuropeptide Y/peptide YY receptor Y2 that contribute to pharmacological differences between receptor subtypes. Neuropeptides 45, 293-300, (2011). Epub 22 Jun 2011. PMID: 21696823.

154. Fällmar, H., Sundström, G., Lundell, I., Mohell, N., and Larhammar, D. Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties. Comp. Biochem. Physiol. 160, 166-173 (2011). Epub 10 Aug 2011. PMID: 21855645.

155. Brodin, L., Jakobsson, J., Ackermann, F., Anderson, F., Larhammar, D., and Löw, P. Regulation of synaptic vesicle budding and dynamin function by an EHD ATPase. J. Neuroscience 31, 13972-13980 (2011). PMID: 21957258.

156. Ocampo Daza, D., Lewicka, M., and Larhammar, D. The oxytocin-vasopressin receptor family has at least five members in the gnathostome lineage, including two distinct V2 subtypes. Gen. Comp. Endocrinol. 175, 135-143 (2012). Epub 28 Oct. 2011. PMID: 22057000.

157. Åkerberg, H., Wilsson, E., Sallander, M., Hedhammar, Å., Lagerstedt, A.-S., Larhammar, D., and Meyerson, B. A test for personality characteristics (TFPC) in dogs used in research. J. Vet. Behav. (in press).

158. Sundström, G., Xu, B., Larsson, T. A., Heldin, J., Bergqvist, C. A., Fredriksson, R, Conlon, J. M., Lundell, I., Denver, R. J. and Larhammar, D. Characterization of the neuropeptide Y system in the frog Silurana tropicalis (Pipidae): Three peptides and six receptor subtypes. Gen. Comp. Endocrinol. 177, 322-331 (2012). Epub 4 May 2012. PMID: 22565163.

159. Hultqvist, G., Ocampo Daza, D., Larhammar, D., and Kilimann, M. W. Evolution of the vertebrate paralemmin gene family: Ancient origin of gene duplicates suggests distinct functions. PLoS One 7(7):e41850 (2012). PMID: 22855693.

160. Lagman, D., Sundström, G., Ocampo Daza, D., Abalo, X. M., and Larhammar, D. Expansion of transducin subunit gene families in early vertebrate tetraploidizations. Genomics 100, 203-211 (2012). Epub 17 July 2012. PMID: 22814267.

161. Ocampo Daza, D., Sundström, G., Bergqvist, C. A., and Larhammar, D. The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements. BMC Evol. Biol. 12, 231 (2012). PMID: 23194088.

162. Xu, B., Sundström, G., Kuraku, S., Lundell, I., and Larhammar, D. Cloning and pharmacological characterization of the neuropeptide Y receptor Y5 in the sea lamprey, Petromyzon marinus. Peptides 39, 64-70 (2013). PMID: 23178200. 

163. Larhammar, D. and Bergqvist, C.A.: Ancient grandeur of the vertebrate neuropeptide Y system shown by the coelacanth Latimeria chalumnae. Front. Neurosci. 7, 27 (2013). PMID: 23483106.

164. Sundström, G., Larsson, T. A., Xu, B., Heldin, J., Lundell, I. and Larhammar D. Interactions of zebrafish peptide YYb with the neuropeptide Y-family receptors Y4, Y7, Y8a and Y8b. Front. Neurosci. 7, 29 (2013). PMID: 23508731.

165. Xu, B., Fällmar, H., Boukharta, L., Gutiérrez-de-Terán, H., Pruner, J., Lundell, I., Mohell, N., Åqvist, J., and Larhammar, D. Mutagenesis and computational modeling of the human G protein-coupled receptor Y2 for neuropeptide Y and peptide YY. Biochemistry 52, 7987-7998 (2013). PMID: 24111902.

166. Lagman, D., Ocampo Daza, D., Widmark, J., Abalo, X. M., Sundström, G., and Larhammar, D. The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications. BMC Evol. Biol. 13, 238 (2013). PMID: 24180662.

167. Xu, B., Varasteh, Z., Orlova, A., Andersson, K., Larhammar, D., and Björkelund, H. Detecting ligand interactions with G protein-coupled receptors in real-time on living cells. Biochem. Biophys. Res. Comm. 441, 820-824 (2013). PMID: 24111902.

168. Larhammar, D. and Lagman, D. Turtle ghrelin. Comment on:"The draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan." Nature Genetics 46, 524-525 (2014). PMID: 24866184

169. Stålberg, G., Ekselius, L., Lindström, L. H., Larhammar, D., and Boden, R. Neuropeptide Y, social function and long-term outcome in schizophrenia. Schizophr. Res. 156, 223-227 (2014). PMID: 24799298.

170. Cardoso, J. C. R., Félix, R. C., Bergqvist, C. A., and Larhammar, D. New insights into the evolution of vertebrate CRH (corticotropin-releasing hormone) and invertebrate DH44 (diuretic hormone 44) receptors in metazoans. Gen. Comp. Endocrinol. (2014). PMID: 25230393.

171. Larhammar, D., Bergqvist, C. A., and Xu, B. Unexpected multiplicity of QRFP receptors in early vertebrate evolution. Front. Neurosci., in press (2014).

172. Xu, B., Bergqvist, C. A., Sundström, G., Lundell, I., Vaudry, H., Leprince, J., and Larhammar, D. Characterization of peptide QRFP (26RFa) and its receptor from amphioxus, Branchiostoma floridae. Gen. Comp. Endocrinol., in press (2014).

Review articles and conference proceedings

1. Kämpe, O., Larhammar, D., Wiman, K., Schenning, L., Claesson, L., Gustafsson, K., Pääbo, S., Hyldig-Nielsen, J. J., Rask, L., and Peterson, P. A. Molecular analyses of the MHC antigens. Genetics of the immune response. Eds.: E. Möller and G. Möller. Proceedings of the 55th Nobel Symposium, Plenum Publishing Corporation, New York. 61-79 (1983).

2. Larhammar, D., Andersson, G., Andersson, M., Bill, P., Böhme, J., Claesson, L., Denaro, M., Emmoth, E., Gustafsson, K., Hammerling, U., Heldin, E., Hyldig-Nielsen, J. J., Lind, P., Schenning, L., Servenius, B., Widmark, E., Rask, L., and Peterson, P. A. Molecular analyses of human class II transplantation antigens and their genes. Human Immunology 8, 95-103 (1983).

3. Peterson, P. A., Andersson, G., Bill, P., Böhme, J., Denaro, M., Emmoth, E., Gustafsson, K., Hammerling, U., Hyldig-Nielsen, J. J., Jonsson, A.-K., Kalm, B., Larhammar, D., Schenning, L., Servenius, B., Widmark, E. and Rask, L. Features of Class I and II antigens of the Major Histocompatibility complex at the DNA and protein level. Progress in Immunology V, 171-186 (1983).

4. Rask, L., Gustafsson, K., Larhammar, D., Ronne, H., and Peterson, P. A. Generation of class II antigen polymorphism. Immunol. Rev. 84, 123-143 (1985).

5. Rask, L., Andersson, G., Andersson L., Gustafsson, K., Jonsson, A.-K., Larhammar, D., Servenius, B., and Peterson, P. A. The Evolution of human class II antigens as deduced from sequence analyses. In "Evolution and vertebrate immunity: The antigen receptor and MHC gene families". Eds.: Dan Schulze and Garnett Kelsoe. University of Texas Press, Austin, TX, U. S. A. 363-377 (1987).

6. Ericsson, A., Larhammar, D., McIntyre, K. R., and Persson, H. A molecular genetic approach to the identification of genes expressed predominantly in the neuroendocrine and immune systems. Immunol Rev. 100, 261-277 (1987).

7. Persson, H., Ericsson, A., Hemsén, A., Hökfelt, T., Larhammar, D. Lundberg, J. M., McIntyre, K. R., and Schalling, M. Expression of neuropeptide tyrosine (NPY) messenger RNA and peptide in non-neuronal cells. In "Neuropeptide Y". Eds.: V. Mutt, T. Hökfelt, K. Fuxe & J. M. Lundberg. Karolinska Institute Nobel Conference Series, Raven Press, New York. 43-50 (1989).

8. Andersson, G., Andersson, L., Larhammar, D., and Rask, L. Organization and evolution of the HLA-DRB genes. In NATO ASI Series, Vol. H 59, Molecular Evolution of the Major Histocompatibility Complex. Eds.: J. Klein & D. Klein. Springer-Verlag, Berlin-Heidelberg. 299-311 (1991).

9. Larhammar, D., Blomqvist, A. G., and Wahlestedt, C. The receptor revolution - multiplicity of G-protein-coupled receptors. Drug Design and Discovery 9, 179-188 (1993).

10. Larhammar, D., Söderberg, C., and Blomqvist, A. G. Evolution of the neuropeptide Y family of peptides. In "Neuropeptide Y and Related Peptides". Eds.: C. Wahlestedt and W. F. Colmers. Humana Press, Totowa, New Jersey. 1-41 (1993).

11. Larhammar, D., Blomqvist, A. G., and Söderberg, C. Evolution of neuropeptide Y and its related peptides. Comparative Biochemistry and Physiology 106C, 743-752 (1993).

12. Brodin, L., Söderberg, C., Pieribone, V., and Larhammar, D. Neuropeptides in the spinal cord. In "Neuropeptides in the Spinal Cord - Fundamental and Clinical Aspects". Eds.: Nyberg, F., Sharma, H. S., and Wiesenfeld-Hallin, Z. Progress in Brain Research 104, 61-74 (1995).

13. Larhammar, D. Evolution of neuropeptide Y, peptide YY, and pancreatic polypeptide. Regul. Peptides 62, 1-11 (1996).

14. Larhammar, D. Structural diversity of receptors for NPY, PYY, and pancreatic polypeptide. Regul. Peptides 65, 165-174 (1996).

15. Chatzidimitriou-Dreismann, C. A., Streffer, R. M. F., and Larhammar, D. On 'fractality' and 'linguistic structure' of DNA sequences of living organisms. In "New Frontiers in Theoretical Biology". Ed.: C. A. C. Dreismann. Hadronic Press, Palm Harbor, FL, USA. 153-205 (1996).

16. Larhammar, D. Extraordinary structural diversity of NPY-family receptors. In: "Neuropeptide Y and Drug Development". Eds.: Grundemar, L. and Bloom, S. R. Academic Press, London. 87-105 (1997).

17. Larhammar, D., Arvidsson, A.-K., Berglund, M. M., Lundell, I., Salaneck, E., Söderberg, C., Starbäck, P., Wraith, A., and Gehlert, D. R. Evolution of neuropeptide Y and its receptors. In "Advances in Comparative Endocrinology", Proceedings of the XIIIth International Congress of Comparative Endocrinology. Eds.: Kawashima, S. and Kikuyama, S. Monduzzi Editore, Bologna (Italy), 551-557 (1997).

18. Larhammar, D., Söderberg, C., and Lundell, I. Evolution of the neuropeptide Y family and its receptors. In "Trends in Comparative Endocrinology and Neurobiology". Ed.: Vaudry, H. Ann. New York Acad. Sci. 839, 35-40 (1998).

19. Michel, M., Beck-Sickinger, A., Cox, H., Doods, H. N., Herzog, H., Larhammar, D., Quirion, R., Schwartz, T., and Westfall, T. XVI. International Union of Pharmacology Recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev. 50, 143-150 (1998).

20. Lundin, L.-G. and Larhammar, D. Paralogous genes and nervous systems. In "Genetics and Psychiatric Disorders". Wenner-Gren International Series. Ed.: Wahlström, J. Pergamon. Vol. 69. 27-56 (1998).

21. Lundell, I., Berglund, M. M., and Larhammar, D. Functional expression and binding of the Y4 receptor in different species. Methods Mol. Biol. 153, 45-51 (2000).

22. Cerdá-Reverter J. M. and Larhammar, D. Neuropeptide Y family of peptides: structure, anatomical expression, function, and molecular evolution. Biochem. Cell Biol. 78, 371-392 (2000).

23. Larhammar, D., Wraith, A., Berglund, M. M., Holmberg, S. K. S., and Lundell, I. Origins of the multiple NPY-family receptors in mammals. Peptides 22, 295-307 (2001).

24. Larhammar, D., Fredriksson, R., Salaneck, E., Larsson, T. A., Holmberg, S. K. S. Lundell, I., and Larson, E. T. Evolution of vertebrate neuropeptide Y receptors. Proceedings of the 21st Conference of European Comparative Endocrinologists. Eds: Keller, R., Dircksen, H., Sedlmeier, D., and Vaudry, H. Monduzzi Editore, Bologna (Italy), 17-22 (2002).

25. Lundin, L.-G., Larhammar, D., and Hallböök, F. Paralogous genes and gene duplications. Encyclopedia of the Human Genome (Macmillan) (3 pages) (2003).

26. Lundin, L.-G., Larhammar, D. and Hallböök, F. Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates. Journal of Structural and Functional Genomics 3, 53-63 (2003).

27. Larhammar, D., Fredriksson, R., Larson, E. T., and Salaneck, E. Phylogeny of NPY-family peptides and their receptors. In "Neuropeptide Y and Related Peptides", Handbook of Experimental Pharmacology. Ed.: Martin C. Michel. Springer-Verlag, Berlin-Heidelberg, 75-100 (2004).

28. Larhammar, D. "Neuropeptide Y, Evolution of". The Encyclopedia of Endocrine Diseases (Elsevier) 3, 343-345 (2004).

29. Larhammar, D. and Salaneck, E. Molecular evolution of NPY receptor subtypes. Neuropeptides 38, 141-151 (2004).

30. Larhammar, D. Preface: The Beauty of the Comparative Approach. Upsala Journal of Medical Sciences Suppl. 56, 3-6 (2005).

31. Vaudry, H., Do Rego, J. L., Beaujean-Burel, D., Leprince, J., Galas, L., Larhammar, D., Fredriksson, R., Luu-The, V., Pelletier, G., Tonon, M. C., and Delarue, C. Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides. In "Hormones and the Brain". Ed.: Kordon et al. Springer-Verlag, Berlin-Heidelberg, 99-109 (2005).

32. Conlon, J. M. and Larhammar, D. The evolution of neuroendocrine peptides. Gen. Comp. Endocrinol. 142, 53-59 (2005).

33. Larhammar, D., Flik, G., Roubos, E., Schoofs, L., and Vaudry, H. Preface: The Beauty of the Comparative Approach. In "Trends in Comparative Endocrinology and Neurobiology". Ed.: Vaudry, H., Roubos, E., Schoofs, L., Flik, G., and Larhammar, D. Annals of the New York Academy of Sciences 1040, xv-xix (2005). (Modified version of article 30.)

34. Bromée, T., Conlon, J. M., and Larhammar, D. Bradykinin receptors in the zebrafish (Danio rerio). Ann. N. Y. Acad. Sci. 1040, 246-248 (2005).

35. Larsson, T. A., Olsson, F., Sundström, G., Brenner, S., Venkatesh, B., and Larhammar, D. Pufferfish and zebrafish have five distinct NPY receptor subtypes, but have lost appetite receptors Y1 and Y5. Ann. N. Y. Acad. Sci. 1040, 375-377 (2005).

36. Mathieu, M., Trombino, S., Argenton, F., Larhammar, D., Vallarino, M. Developmental expression of NPY/PYY receptors zYb and zYc in zebrafish. Ann. N. Y. Acad. Sci. 1040, 399-401 (2005).

37. Sundström, G., Larsson, T. A., Brenner, S., Venkatesh, B., and Larhammar, D. Ray-fin fish tetraploidization gave rise to pufferfish duplicates of NPY and PYY, but zebrafish NPY duplicate was lost. Ann. N. Y. Acad. Sci. 1040, 476-8 (2005).

38. Salaneck, E., Larson, E. T., Larsson, T. A., and Larhammar, D. Effects of a teleost tetraploidization on neuropeptide Y receptor gene repertoire in ray-finned fishes. Ann. N. Y. Acad. Sci. 1040, 457-459 (2005).

39. Larhammar, D. and Salaneck, E. Evolutionary perspective on  the NPY-PYY-PP peptides and their receptors. In "NPY family of peptides in inflammation, immunde disorders, angiogenesis and cancer: Genes diseases and therapeutics". Ed.: Z. Zukowska and G. Z. Feuerstein. Book series: Progress in Inflammation Research. Series editor: M. J. Parnham. Birkhäuser, Basel (Switzerland). 3-28 (2005).

40. Larhammar, D. and Vanden Broeck, J. Peptide hormone and receptor evolution. Summary and discussion of session at the 26th CECE, 2006. Gen. Comp. Endocrinol. 153, 147 (2007). PMID: 17666205.

41. Lundin, L.-G., Larhammar, D., and Hallböök, F. Paralogous genes and gene duplications. Encyclopedia of the Human Genome (Macmillan) (4 pages) (2008). Updated version of encyclopedia entry published in 2002.

42. Larhammar, D. Neuropeptide phylogeny and evolution. Encyclopedia of Neuroscience. Editor-in-chief: Larry R. Squire. Academic Press, Oxford. 873-879 (2009). E-pub 2008.

43. Larhammar, D., Sundström, G., Dreborg, S., Ocampo Daza, D., and Larsson, T. A. Major genomic events and their consequences for vertebrate evolution and endocrinology. In: Trends in Comparative Endocrinology and Neurobiology. Ed.: H. Vaudry. Ann. N. Y. Acad. Sci. 1163, 201-208 (2009). PMID: 19456340.

44. Larhammar, D., Dreborg, S., Larsson, T. A., and Sundström, G. Early duplications of opioid receptor and peptide genes in vertebrate evolution. In: Trends in Comparative Endocrinology and Neurobiology. Ed.: H. Vaudry. Ann. N. Y. Acad. Sci. 1163, 451-453 (2009). PMID: 19456384.

45. Ocampo Daza, D., Sundström, G., Larsson, T. A., and Larhammar, D. Evolution of the growth hormone-prolactin-somatolactin system in relation to vertebrate tetraploidizations. In: Trends in Comparative Endocrinology and Neurobiology. Ed.: H. Vaudry. Ann. N. Y. Acad. Sci. 1163, 491-493 (2009). PMID: 19456396.

46. Do Rego, J. L., Seong, J. Y., Burel, D., Luu-The, V., Larhammar, D., Tsutsui, K., Pelletier, G., Tonon, M. C., and Vaudry, H. Steroid biosynthesis within the frog brain: a model of neuroendocrine regulation. In: Trends in Comparative Endocrinology and Neurobiology. Ed.: H. Vaudry. Ann. N. Y. Acad. Sci.1163, 1950-1963 (2009). PMID: 19456330.

47. Nässel, D. and Larhammar, D. Book chapter: Neuropeptides and peptide hormones. In: Neurosciences. From molecule to behavior: A university textbook. (Springer). Ed.: C. G. Galizia and P.-M. Lledo. 213-237 (2013). ISBN 978-3-642-10768-9 (http://www.springer.com/springer+spektrum/biowissenschaften/neurowissenschaft/book/978-3-642-10768-9)

48. Larhammar, D., Sundström, G., and Dores, R. M. Book chapter: Evolution of the opioid system. In: Handbook of Biologically Active Peptides, Second edition (Elsevier). Editor: A. Kastin. Section Editor: F. Nyberg. 1562-1569 (2013).

49. Lundin, L.-G., Larhammar, D., and Hallböök, F. Polyploidy and paralogous chromosome regions. Encyclopedia of Life Sciences, a web-based encyclopedia (Wiley) (6 pages) (2013). Rewritten version of text from 2008 with new figures. (http://www.els.net/WileyCDA/ElsArticle/refId-a0005072.html)

50. Widmark, J and Larhammar, D. Evolution of voltage-gated sodium channels. Encyclopedia of Life Sciences, a web-based encyclopedia (Wiley). (4 pages) (2013). (http://www.els.net/WileyCDA/ElsArticle/refId-a0024936.html)

51. Tostivint, H., Ocampo Daza, D., Bergqvist, C. A., Quan, F. B., Bougerol, M., Lihrmann, I., and Larhammar, D. Molecular evolution of somatostatin and urotensin II systems. J. Mol. Endocrinol. 52, T61-86 (2014). PMID: 24740737.

52. Larhammar, D., Bergqvist, C. A., and Sundström, G. Ancestral vertebrate complexity of the opioid system. Vitam. Horm.,  in press (2014).

Contact

Dan Larhammar

Group leader:

Prof. Dan Larhammar

e-mail: dan.larhammar@neuro.uu.se

 

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