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Open-angle glaucoma

Open-angle glaucoma is a common disease, accounting for a substantial proportion of blindness in most parts of the world. In advanced stages, glaucoma is of serious health concern, leading to loss of mobility and personal independence. Open-angle glaucoma is an affliction of old age. In Caucasian populations, 2% in the age range 40 years and older have the disease.

Essentially, open-angle glaucoma is an optic neuropathy characterized by progressive loss of optic nerve fibres, resulting in changes of the optic nerve head and visual field defects. Increased intraocular pressure is the principal risk factor and the only treatable risk factor. Other risk factors are higher age, a positive family history, myopia and pseudoexfoliation.

Pseudoexfoliation is an age-related disorder, characterized by the production and accumulation of a fibrillar material in the anterior segment of the eye. Common sequence variants in a gene involved in elastin formation have been found the confer susceptibility to open-angle glaucoma.

The major interest of the glaucoma research group is epidemiological aspects of open-angle glaucoma and pseudoexfoliation. Basic molecular studies on pseudoexfoliation are also a field of interest. Evaluation of optic nerve function and morphology in open-angle glaucoma is another project.

 

Contact

Curt Ekström

Group leader:

Curt Ekström

e-mail: curt.ekstrom@neuro.uu.se