Epilepsy

Epilepsy is a chronic disease characterised by recurrent seizures. In Sweden approximately 60 000 people have epilepsy. Epilepsy is not a single disease, but rather an expression of many different brain disorders.

In 50% of people that have a first seizure the seizure is an isolated phenomenon. Epilepsy is associated to neuropsychological difficulties and epilepsy report reduced quality of life. Epilepsy is also associated with increased mortality (sudden unexpected death, SUD).

Anti-epileptic drugs are useful in controlling seizures but 25% of patients are medically resistant and continue to have seizures despite treatment. Surgical treatment may be an alternative for these patients.

Research programs:

 ·Role of exposure of antiepiletic drugs in utero in the prevention of later cognitive impairment in children to parents with epilepsy

·Epidemiological studies on SUD in a population with epilepsy

·Localisation of epileptogenic lesion with PET

·PET studies of the blood brain barrier in patients with medically intractable epilepsy

·Electrolyte disturbances and other metabolic rearrangements in association with acute symptomatic seizures.

·Studies of neuroexcitation using trancranial magnetic stimulation in stroke and in patients undergoing long-term video-EEG monitoring as part of epilepsy surgery investigation.

Members of the research group:

Torsten Danfors

Imad Halawa

Eva Kumlien

Peter Mattsson

Johan Zelano