Se samtliga publikationer

Projects

Biomarkers

We continue our expansion of data on circulating microRNAs in the sera of MG patients as biomarkers. The levels of the most sensitive biomarker, miR150-5p, were reduced in patients with immunosuppressive treatment. We also established the novel biomarker let7-family of miRNAs in MG patients with MuSK antibodies (Punga et al, 2016, J Neuroimmunol), which support the etiological differences between AChR antibody and MuSK antibody seropositive MG.  These potential biomarkers in the sera of MG patients are important, since no biomarkers have been available to date. We will now continue to elucidate the role of these immuno-miRNAs in the processes of the autoimmune response more specifically and in the neuromuscular transmission, both in-vivo and in-vitro.

Exercise studies in MG

Further, we have established neurophysiological parameters to assess the effects upon physical training (Molin&Punga, 2016, in press) that will be used in future studies of physical exercise in MG patients.

Novel cutting-edge model systems to study diseases at the neuromusuclar junction (NMJ)

We have been able to record postsynaptic spikes from generated muscle cells (myocytes) on a high-density electrode chip. The chip contains an array of 26.400 platinum electrodes at a density of 3265 electrodes per mm2. A subset of 1024 electrodes can be read out simultaneously and can be stimulated through the 32 on-chip stimulation buffers. Recently, this model system was able to record large spikes along many axonal sites (Lewandowska et al, 2015). We are now expanding on this model to include motor neuron recordings, to finally reach an NMJ on a chip. 

Contact

Group leader:

Anna Rostedt Punga

E-mail: anna.rostedt.punga@neuro.uu.se

Anna Rostedt Punga, Klinisk neurofysiologi får anslag från Franska muskelsjukdomsstiftelsen, AFM

Anna Rostedt Punga har med sitt forskarteam glädjande erhållit 25000 euro från Franska muskelsjukdomsstiftelsen, AFM; Association francaise contre les myopathies, i samarbete med Dr Laure Strochlic från INSERM, Paris, för att utröna effekten av antikroppar mot CRD-domänen av MuSK på skelettmuskler och eventuell koppling till muskeltrötthet och myasthenia gravis.

Read more about myasthenia gravis

Vad vet vi i dagsläget om myasthenia Gravis: Länk till intervju med Dr Anna Rostedt Punga via Neuroförbundet

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