Functional pharmacology

The team at functional pharmacology studies pharmacological, genetic and behavioural aspects of central regulation of food intake using human, animal and insect models.

We study the causes of obesity looking at reward mechanisms, cognition and functional role of sleep (sleep deprivation). We functionally characterize newly identified genes that code for solute carriers, GPCRs and other membrane bound protein that are involved in food intake regulation, reward, obesity and anorexia. We have special focus on psychological pathology related to children and adolescents. We perform detailed neuronal expression mapping, association to human body weight phenotypes using human genetics and epigenetics, investigation of gene function using conditional (Cre-Lox) knockout mice, genetic models in fruit flies, clinical studies on nutrition, cognition, neuroimaging (fMRI), sleep, and pathologies of obesity and anorexia. Neuronal networks of food intake with emphasis on reward functions are of high interest as well as the transporters and receptors that act as key nodes. We use bioinformatics studies to identify and characterize new genetic elements and we study the evolutionary mechanism that shaped large gene families among membrane bound proteins. The research group was ranked in 2011 at the highest category of “top international class” by external international panel evaluation of Uppsala University (KoF2011) stating that the “research output of this group is exceptional” with projects “highly relevant for society”. The team aims to create a multidisciplinary environment with good career opportunity for PhD students and post doctoral fellows. The team is very productive with series of high impact publications and high number of citations. The unit is responsible for teaching in pharmacology at the medical and biomedical programs, a master program in biomedicine as well as number of other courses.

Key persons:

Helgi B. Schiöth, Professor in Pharmacology, Head of unit

Robert Fredriksson, Associate Professor, Reader, Director of undergraduate studies in Pharmacology

Åsa Mackenzie, Researcher

Madeleine Le Grevés, Associate Senior Lecturer in Pharmakologi

Michael Williams, researcher

Christian Benedict, Reader

Samantha Brooks, researcher

Josefin Jacobsson, Post doc

Pleunie Hogenkamp, Post doc

Sonchita Bagchi, Post doc

Ashley Hutchinsson, Post doc

Kontakt

Group leaders:

Prof. Helgi Schiöth

e-mail: helgi.schioth@neuro.uu.se

Robert Fredriksson

e-mail: robert.fredriksson@neuro.uu.se

 

Do you want to research at the Department of Neuroscience?

Our groups of researcher are continuously loooking for new collaborative partners, post-doctoral fellows, Ph.D. students and project students. We are able to offer a range of different projects that can be tailored to your interests. Read more about our groups of researchers and contact our group leaders.

Read more about our recruitment here.